Spectroscopy and Chemometrics News Weekly #48+49, 2016

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Near Infrared

Cannabis Analysis – On-Site Determination of Cannabis Strength using FT-IR Spectrosocopy FTNIR Ingredients LINK

Near Infrared NIRS, GC and HPLC Applications in Cannabis Testing THC CBD LINK

Raman

What happens when you use Raman spectroscopy to discriminate between brands of extra-virgin olive oil LINK

Raman spectroscopy of chocolate bloom LINK


Hyperspectral

Hyperspectral photoluminescence imaging of defects in solar cells | solar cells via LINK


Agriculture

Soy meal Protein bands LINK

Vitamin C distribution in acerola fruit by near infrared hyperspectral imaging HSI LINK


Equipment

Spectroscopists need freedom to analyse their spectral data, uncoupled from spectrometer hardware! LINK!


Chemometrics

Quality parameters in Castanhola fruit by NIRS to development of prediction models using PLS … in laboratory scale LINK

Monitoring Process-Water Quality Using NIRS and PLSR with Prediction Uncertainty Estimation LINK


Food & Feed

NIR diffuse reflection analysis of fruit – Food Science & Technology LINK


Agriculture

Innovation für die Obstwirtschaft: Neue Ansätze zur Messung und Vorhersage der Apfelqualität MONALISA LINK


Other

Hackers beware! Faking 3D-printed products just got harder. Full-spectrum spectroscopy for the win! LINK!

3D NDVI, using a low cost multi spectral camera. LINK

On the Generation of Random Multivariate Data | Multivariate Data LINK


CalibrationModel.com

Spectroscopy and Chemometrics News Weekly 46+47, 2016 | Spectroscopy NIRS Multivariate DataAnalysis Software LINK

Spektroskopie und Chemometrie Neuigkeiten Wöchentlich 46+47, 2016 | NIRS Spektroskopie Multivariate DatenAnalyse LINK

Spettroscopia e Chemiometria Weekly News 46+47, 2016 | NIRS Spettroscopia Chemiometria LINK


We make NIR Chemometrics easy

Hi, we’re CalibrationModel. Our aim is to transform your NIR data to superior calibration models. We do this by using knowledge driven software applying good practices and rules from literature, publications, regulatory guidelines and more. Our service is used by NIR specialists to deliver a valuable model for their NIR analysis measurements. With CalibrationModel services, NIR specialists can find out how their NIR Data can be robust and optimally modeled by which data preprocessing and wavelength selection, etc. You can implement CalibrationModel in a matter of minutes using our contact form and send your NIR data to receive optimized model settings as a blueprint.
NIR specialists (Spectroscopist, Chemometricians) love perfect models. They’re curious about how to improve their models even further, because all NIR models need continuous maintenance and updates.
Using CalibrationModel services, NIR Specialists can deliver real value to their measurement results through powerful model optimization capabilities.
CalibrationModel We make NIR Chemometrics easy. Near-Infrared Data Modeling Calibration Service

Theory of Sampling (TOS)

What is Theory of Sampling (TOS)? TOS is a theory about the sampling of materials. Here are some recommended links. Links Gy’s sampling theory TOS forum edited by Professor Kim H. Esbensen Presentations Representative Sampling – a critical success factor for all analytical endeavors (incl. NIR), Kim Esbensen, IDRC 2014 Papers Theory of sampling (TOS) versus measurement uncertainty (MU) – A call for integration, Kim H. Esbensen, Claas Wagner Books Process Analytical Technology: Spectroscopic Tools and Implementation Strategies for the Chemical and Pharmaceutical Industries, Second Edition, Chapter 3. Process Sampling: Theory of Sampling – the Missing Link in Process Analytical Technologies (PAT), Katherine A. Bakeev, Kim H. Esbensen and Peter Paasch-Mortensen Related: Why NIR Method Maintenance?

How to develop near-infrared spectroscopy calibrations in the 21st Century?


The Problem

Calibration modeling is a complex and very important part of NIR spectroscopy, especially for quantitative analysis. If the model is badly designed the best instrument precision and highest data quality does not help getting good and robust measurement results. And NIR Spectroscopy requires periodically recalibration and validation.


How are NIR models built today?

In a typical usage in industry, a single person is responsible to develop the models (see survey). He or she uses a Chemometric software that has a click-and-wait working process to adjust all the possible settings for the used algorithms in dialogs and wait for calculations and graphics and then to think about the next modeling steps and the time is limited to do so. Do we expect to find the best use-able or optimal model that way? How to develop near-infrared spectroscopy calibrations in the 21st Century?


Our Solution

Why not put all the knowledge a good model builder is using into software and let the machines do the possibilities of calculations and presenting the result? Designing the software that way, that the domain knowledge is built-in, not just only the algorithms for machine learning and make it possible to scale the calculations to multi-core computers and up to cloud servers. Extend the Chemometric Software with the Domain Knowledge and make as much computer power available as needed.

As it was since the beginning

User  → Chemometric Software → one Computer → some results to choose from

==> User’s time needed to click-and-wait for creating results

Our Solution

User → (Domain Knowledge → automatized Chemometric Software) → many Computers → the best models

==> User’s time used to study the best models and reasoning about his product / process

Note that the “Domain Knowledge” here does perfectly support the User’s product and process knowledge to get the things done right and efficient.


Scaling at three layers

  • Knowledge : use the domain knowledge to drive the Chemometric Software
  • Chemometric Software : support many machine learning algorithms and data pre-processings and make it automatic
  • Computer : support multi-core calculations and scale it to the cloud

The hard part in doing this, is of course the aggregation of the needed domain knowledge and transform it into software. The Domain Knowledge for building Chemometric NIR Spectroscopic models is well known and it’s huge and spreads multiple disciplines. Knowledge-driven software for computing helps to find the gold needle in the haystacks. It’s all about scaling that makes it possible. See Proof of Concept.


New possibilities

  • NIR users can get help working more efficient and getting better models.
  • New types of applications for NIR can be discovered.
  • Evaluation of NIR Applications to replace conventional analytical methods.
  • Hopeless calibrations development efforts can be re-started.
  • Higher model accuracy and robustness can be delivered.
  • Automate the experimental data part of your application study.
  • Person independent optimization will show new solutions, because it’s not limited by a single mindset => combining all the aggregated knowledge and its combinations.
  • Software independent optimization will show new solutions, because none of vendor specific limitations and missing algorithms are present => combining all open available algorithms and there permutations.
  • Computing service is included.

Contact us for trial

Your NIR data is modeled by thousands of different useful calibration models and you get the best of them! That was not possible before in such a easy and fast way! See How it works

Summary of the NIR Chemometric survey polls

Summary of the NIR Chemometric survey polls (as of end of Sept. 2013)

The interesting finding is that most of the answers fit the following pattern. The most companies that use NIR have one NIR Instrument and only one employee that is able to develop NIR calibrations. For that the most common off-the-shelf chemometrics program is used and spent 2 hours or over a month and therefore gets no calibration training about the complex topics like Chemometrics and NIR Spectroscopy or only once (introduction). The calibration maintenance ranges from never to 3 times a year. Interestingly, there was no one who uses portable NIR instruments. We continue our surveys, for the discovery of new trends. Conclusion Seeing this picture, we think that there is huge potential to improve the calibrations. Advanced knowledge can help individuals to build the calibrations with best practices and improve their models accuracy and reliability. Once the decision and investment in NIR technology is done, you should get the best out of your data, because this extra NIR performance can be given by calibration optimization. We offer this as an easy to use and independent service.

Customized NIR Calibrations

Increase Your Profit with optimized NIR Accuracy


We help you to find the optimal settings for higher NIR accuracy and reliability.

You can build your own custom NIR calibration model with this valuable settings.

We offer a quantitative NIR Calibration development and optimization service.

New: White Paper about the details, what’s behind.


Improve NIR Measurement Accuracy

  • going closer to your product specification limits and maximize profitability
  • optimizing your models yield to process optimization and optimizing productivity
  • compete against other NIR vendors in a feasibility study (NIR salesman)

Easy to use

  • compatible with any NIR vendor
  • no installation, no learning
  • quantitative NIR Calibration Development as a Service

Safety

  • help users avoid common pitfalls of method development
  • before you validate and approve your solution for use in production process:
    • check if a better calibration can be found,
    • compare your calibration with other experts solutions.

Speed

  • no cumbersome trial-and-error modeling steps
  • calculation time is spent on our high performance infrastructure
  • fast results, developed calibrations within days

Fix price

  • fix costs, depends only on data size (not hourly rate for service)
  • huge saving in method development costs
  • easy to plan
More benefits, for whom and where, learn more , contact

NIR Spectroscopy and Chemometric surveys, inquiry, polls and assessments (Part 3)


10. NIR in Supply Chain
Where in the supply chain are your NIR instruments located?

11. NIR Usage
How long has your company used NIR spectroscopy?

12. NIR instruments
How many NIR instrument units are in use in your company?

13. NIR Mobile
How much is the mobile hand-held percentage of total NIR devices in your company?

14. Calibration Source
How do you get the NIR Calibrations developed?

15. Calibration Training
How often do the operators get training about NIR Spectroscopy and Chemometrics?

16. NIR PreCalibrations
How many NIR Pre-Calibration, NIR factory calibrations or NIR starter calibrations have you in use?

17. Calibration Spectra
How many Spectra does your quantitative Calibration have in average?

Please vote and see the assessments below.

Part 1, Part 2
NIR in Supply Chain
Where in the supply chain are your NIR instruments located?
NIR Usage
How long has your company used NIR spectroscopy?
NIR instruments
How many NIR instrument units are in use in your company?
NIR Mobile
How much is the mobile hand-held percentage of total NIR devices in your company?
Calibration Source
How do you get the NIR Calibrations developed?
Calibration Training
How often do the operators get training about NIR Spectroscopy and Chemometrics?
NIR PreCalibrations
How many NIR Pre-Calibration, NIR factory calibrations or NIR starter calibrations have you in use?
Calibration Spectra
How many Spectra does your quantitative Calibration have in average?

Part 1, Part 2

NIR Calibration Modeling

The majority of NIR calibrations are generated using a small number of different parameter settings and all too often are restricted to the time a user has available, their spectroscopic and chemometric knowledge and their ability (tedious use of the software) to choose and combine all the possible parameter settings required for good calibrations.

There are many published standards and guidelines (protocols) available for developing NIR calibrations from Standards Consortium such as ASTM, EMEA, ICH, IUPAC, ISO, USP, PASG etc. as well as many good recommendations and guidelines found in various textbooks and papers.

The difficulty with so many ‘Protocols’ for the NIR user is to have them all available and in their thought processes during calibration work and in addition to execute, check and challenge all calibrations generated manually. This is time consuming and sometimes boring repetitive work.

To simplify this for the person generating the NIR Calibrations, we have collected the good practices protocols and integrated them into our service that automates the calibration building and evaluation procedures.

to part 2

NIR Spectroscopy and Chemometric surveys, polls and assessments (Part 2)


5. Calibration Precision
What do you believe, can NIR calibration models be more precise than reference values?

6. Calibration Maintenance
How often do you update your quantitative calibrations per year?

7. Quantitative Calibrations
How many quantitative (%) calibrations do you have in use?

8. Quantitative Parameters
In all your quantitative calibrations, how many parameters (properties) you have in total?

9. Qualitative Calibrations
How many qualitative (identification) calibrations do you have in use?

Please vote and see the assessments below.
Part 1, Part 3
Calibration Precision
What do you believe, can NIR calibration models be more accurate than reference method?
Calibration Maintenance
How often do you update your quantitative calibrations per year?
Quantitative Calibrations
How many quantitative (%) calibrations do you have in use?
Quantitative Parameters
In all your quantitative calibrations, how many parameters (properties) you have in total?
Qualitative Calibrations
How many qualitative (identification) calibrations do you have in use?

Part 1, Part 3

NIR Spectroscopy and Chemometric surveys, polls and assessments


1. Calibration Developers
How many persons in your company are able to develop a NIR Calibration?


2. Calibration Development
How much time do you spend to develop a calibration model?


3. Chemometric Software / Spectroscopy Software
Which Chemometric Software are you using for NIR?


4. NIR Spectrometer Brand
Which NIR Spectrometer Brand do you use?


Please vote and see the assessments below.

Part 2, Part 3
Calibration Developers
How many persons in your company are able to develop a NIR Calibration?
Calibration Development
How much time do you spend to develop a calibration model?
Chemometric Software
Which Chemometric Software are you using for NIR?
NIR Spectrometer Brand
Which NIR Spectrometer Brand do you use?


Part 2, Part 3